You are invited to take part in a study to investigate a new vaccine against Marburg virus. The study is being led by the Oxford Vaccine Group, which is part of the University of Oxford. The study will take place at the Oxford Vaccine Group, Centre for Clinical Vaccinology & Tropical Medicine (CCVTM).
If you are aged between 18 and 49 years (group B) or 60 and 80 years (group A or group B), in good health and able to attend regular face-to-face visits in Oxford Vaccine Group, Centre for Clinical Vaccinology & Tropical Medicine (CCVTM), Churchill Hospital, Oxford, OX3 7LE you may be eligible to take part. We will reimburse you up to £700 (group B) and £1,060 (group A) for your time, travel and inconvenience.
Purpose of study
We will study how the body reacts to a combination of the flu virus and pneumococcal bacteria. We will use a nasal flu vaccine (LAIV) to copy how the immune system reacts to the flu, and a safe method of putting pneumococcal bacteria in the nose. We aim to develop new treatments and vaccines that can be given by the nose.
Study details
There will be two study arms, Group A and Group B. Group A will have pneumococcal bacteria on Day 0 and LAIV on Day –3 OR Day 3, with administration blinded. Participants in Group B will have LAIV alone.
Group A - Participants will have up to nine study visits at <insert site>. Blood samples and samples from the nose, mouth and throat to measure the immune response to the vaccine, will be taken at follow up visits. We will also ask you to take some samples of nasal fluid, with special blotting paper, and saliva between the visits.
Group B - Participants will have five study visits at <insert site>. The LAIV vaccine will be given on day 0. Blood samples and samples from the nose, mouth and throat to measure the immune response to the vaccine, will be taken at follow up visits. We will also ask you to take some samples of nasal fluid, with special blotting paper, and saliva between the visits.
You may also be invited for Fine Needle Aspirate sampling as an optional visit.
Further information
If you have further questions after reading this, please contact us on:
Email: info@ovg.ox.ac.uk
Phone: 01865611400