A Study Exploring Whooping Cough Protection in Children and Adults

The Oxford Vaccine Group are conducting a research study to learn more about vaccines that can prevent pertussis infection. Pertussis infection, also known as whooping cough, affects the lungs and airways and can cause severe illness in young infants and prolonged respiratory symptoms in older children and adults. Pertussis vaccines are already given to all babies in the UK as well as to pre-school children and women in pregnancy.

Why are we doing this study?

The level of protection against pertussis infection gradually falls with increasing time after being given a vaccine. There are many questions about how long protection lasts and about the immune response to further booster doses of vaccine given at different ages. This study will provide information to answer some of these questions.

What happens in this study?

  • We are looking to enrol healthy children aged 7- 15 years old and adults aged 20-34 and 60-70 years old who are registered with a GP in the Thames Valley area
  • All participants would receive a whooping cough vaccine at their first visit
  • Children would have a total of 4 visits with 4 blood tests whereas adults would have 5 visits with 5 blood tests over a 12 month period
  • Adult participants will be reimbursed for their time, inconvenience and travel, receiving up to £225 if they remain in the study for the entire period
  • Child visits would take place at home or a nearby location whereas adult visits would take place at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM) at the Churchill Hospital
  • Local anaesthetic skin cream would be used for children to reduce any discomfort from blood sampling
  • All participants would have 24 hour telephone access to a study doctor should there be any concerns following vaccinations

Taking part in this research study is completely voluntary.

If you or your child are interested in participating in the study, please read the Study Information Booklet or Parent Study Information Booklet or Information Booklet (7-10yrs) or Study Information Booklet (11-15yrs) as appropriate and complete the self-screening questions below to assess eligibility.

If you would like any further information or to discuss any aspect of the study then please contact us on:

Tel: 01865 611400 or Email: info@ovg.ox.ac.uk

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